General Information

General Information

DRAVP ID DRAVPe01962

Peptide Name Tilapia piscidin 3, TP3

Sequence FIHHIIGGLFSVGKHIHSLIHGH

Sequence Length 23

UniProt ID L0CMD2

Source Oreochromis niloticus

Activity Information

Target Organism FMDV

Assay Plaque forming assay

Activity

[Ref.30012343]Foot-and-Mouth Disease virus(FMDV):Inhibition of viral replication in BHK-21 cells(IC50=2.5±0.2 µg/ml, IC90=25.0±3.2 µg/ml).

Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity

[Ref.30012343]Baby Hamster Kidney cells BHK-21:CC50=39.0±1.2 µg/ml.

Binding Target Not found

Mechanism No mechanism information found in the reference(s).

Structure Information

PDB ID None

Predicted Structure Download No predicted structure available

Linear/Cyclic Linear

N-terminal Modification Free

C-terminal Modification Amidation

Other Modification None

Stereochemistry L

Physicochemical Information

Formula C121H182N36O26

Absent amino acids ACDEMNPQRTWY

Common amino acids H

Mass 2557

Pl 8.79

Basic residues 7

Acidic residues 0

Hydrophobic residues 10

Net charge 7

Boman Index 789

Hydrophobicity 59.13

Aliphatic Index 131.3

Half Life

Mammalian:1.1 hour
Yeast:3 min
E.coli:2 min

Extinction Coefficient cystines 0

Absorbance 280nm 0

Polar residues 6

Literature Information

Literature 1

Title Grouper (Epinephelus coioides) antimicrobial peptide epinecidin-1 exhibits antiviral activity against foot-and-mouth disease virus in vitro.

Pubmed ID 30012343

Reference Peptides. 2018 Aug;106:91-95.

Author Huang HN, Pan CY, Chen JY.

DOI 10.1016/j.peptides.2018.07.003