General Information


DRAVP ID  DRAVPe01962

Peptide Name   Tilapia piscidin 3, TP3

Sequence  FIHHIIGGLFSVGKHIHSLIHGH

Sequence Length  23

UniProt ID  L0CMD2 

Source  Oreochromis niloticus



Activity Information


Target Organism  FMDV

Assay  Plaque forming assay

Activity 

  • [Ref.30012343]Foot-and-Mouth Disease virus(FMDV):Inhibition of viral replication in BHK-21 cells(IC50=2.5±0.2 µg/ml, IC90=25.0±3.2 µg/ml).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

  • [Ref.30012343]Baby Hamster Kidney cells BHK-21:CC50=39.0±1.2 µg/ml.

Binding Target  Not found

Mechanism  No mechanism information found in the reference(s).



Structure Information


PDB ID  None

Predicted Structure Download  No predicted structure available

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Amidation

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  C121H182N36O26

Absent amino acids  ACDEMNPQRTWY

Common amino acids  H

Mass  2557

Pl  8.79

Basic residues  7

Acidic residues  0

Hydrophobic residues  10

Net charge  7

Boman Index  789

Hydrophobicity  59.13

Aliphatic Index  131.3

Half Life 

  •     Mammalian:1.1 hour
  •     Yeast:3 min
  •     E.coli:2 min

Extinction Coefficient cystines  0

Absorbance 280nm  0

Polar residues  6



Literature Information


Literature 1

Title   Grouper (Epinephelus coioides) antimicrobial peptide epinecidin-1 exhibits antiviral activity against foot-and-mouth disease virus in vitro.

Pubmed ID   30012343

Reference   Peptides. 2018 Aug;106:91-95.

Author   Huang HN, Pan CY, Chen JY. 

DOI   10.1016/j.peptides.2018.07.003