General Information

General Information

DRAVP ID DRAVPe01965

Peptide Name Pardaxin P-4

Sequence GFFALIPKIISSPLFKTLLSAVGSALSSSGGQE

Sequence Length 33

UniProt ID P81861

Source Pardachirus marmoratus

Activity Information

Target Organism FMDV

Assay Plaque forming assay

Activity

[Ref.30012343]Foot-and-Mouth Disease virus(FMDV):Inhibition of viral replication in BHK-21 cells(IC50=2.4±0.1 µg/ml, IC90=12.1±1.1 µg/ml).

Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity

[Ref.30012343]Baby Hamster Kidney cells BHK-21:CC50=19.5±3.2 µg/ml.

Binding Target Not found

Mechanism No mechanism information found in the reference(s).

Structure Information

PDB ID 1XC0

Predicted Structure Download DRAVPe01965

Linear/Cyclic Linear

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Stereochemistry L

Physicochemical Information

Formula C154H248N36O45

Absent amino acids CDHMNRWY

Common amino acids S

Mass 3323.88

Pl 8.59

Basic residues 2

Acidic residues 1

Hydrophobic residues 15

Net charge 1

Boman Index 1171

Hydrophobicity 74.55

Aliphatic Index 112.42

Half Life

Mammalian:30 hour
Yeast:>20 hour
E.coli:>10 hour

Extinction Coefficient cystines 0

Absorbance 280nm 0

Polar residues 12

Literature Information

Literature 1

Title Grouper (Epinephelus coioides) antimicrobial peptide epinecidin-1 exhibits antiviral activity against foot-and-mouth disease virus in vitro.

Pubmed ID 30012343

Reference Peptides. 2018 Aug;106:91-95.

Author Huang HN, Pan CY, Chen JY.

DOI 10.1016/j.peptides.2018.07.003