General Information


DRAVP ID  DRAVPe01965

Peptide Name   Pardaxin P-4

Sequence  GFFALIPKIISSPLFKTLLSAVGSALSSSGGQE

Sequence Length  33

UniProt ID  P81861 

Source  Pardachirus marmoratus



Activity Information


Target Organism  FMDV

Assay  Plaque forming assay

Activity 

  • [Ref.30012343]Foot-and-Mouth Disease virus(FMDV):Inhibition of viral replication in BHK-21 cells(IC50=2.4±0.1 µg/ml, IC90=12.1±1.1 µg/ml).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

  • [Ref.30012343]Baby Hamster Kidney cells BHK-21:CC50=19.5±3.2 µg/ml.

Binding Target  Not found

Mechanism  No mechanism information found in the reference(s).



Structure Information


PDB ID  1XC0 

Predicted Structure Download  DRAVPe01965

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  C154H248N36O45

Absent amino acids  CDHMNRWY

Common amino acids  S

Mass  3323.88

Pl  8.59

Basic residues  2

Acidic residues  1

Hydrophobic residues  15

Net charge  1

Boman Index  1171

Hydrophobicity  74.55

Aliphatic Index  112.42

Half Life 

  •     Mammalian:30 hour
  •     Yeast:>20 hour
  •     E.coli:>10 hour

Extinction Coefficient cystines  0

Absorbance 280nm  0

Polar residues  12



Literature Information


Literature 1

Title   Grouper (Epinephelus coioides) antimicrobial peptide epinecidin-1 exhibits antiviral activity against foot-and-mouth disease virus in vitro.

Pubmed ID   30012343

Reference   Peptides. 2018 Aug;106:91-95.

Author   Huang HN, Pan CY, Chen JY. 

DOI   10.1016/j.peptides.2018.07.003