General Information


DRAVP ID  DRAVPe01985

Peptide Name   Peptide5

Sequence  IYALLENAEDYNLVN

Sequence Length  15

UniProt ID  No entry found

Source  Synthetic construct



Activity Information


Target Organism  SARS-CoV-2

Assay  luciferase assay

Activity 

  • [Ref.34328726]SARS-CoV-2:Inhibition of virus entry in HEK293T/ACE2 cells (via inhibition of SRBD:ACE2 interaction)(IC50=9 ± 4 nM, 100% inhibition at 25 µM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

  • No cytotoxicity information or data found in the reference(s) presented in this entry

Binding Target  Spike protein

Mechanism  antagonizes the SARS-CoV-2 S-RBD:ACE2 interaction and inhibits the virus entry.



Structure Information


PDB ID  None

Predicted Structure Download  No predicted structure available

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Amidation

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  C79H120N18O27

Absent amino acids  CFGHKMPQRSTW

Common amino acids  LN

Mass  1753.93

Pl  3.57

Basic residues  0

Acidic residues  3

Hydrophobic residues  7

Net charge  -3

Boman Index  -1520

Hydrophobicity  0.67

Aliphatic Index  136.67

Half Life 

  •     Mammalian:20 hour
  •     Yeast:30 min
  •     E.coli:>10 hour

Extinction Coefficient cystines  2980

Absorbance 280nm  212.86

Polar residues  5



Literature Information


Literature 1

Title   Synthetic Peptides That Antagonize the Angiotensin-Converting Enzyme-2 (ACE-2) Interaction with SARS-CoV-2 Receptor Binding Spike Protein

Pubmed ID   34328726

Reference   J Med Chem. 2022 Feb 24;65(4):2836-2847. 

Author   Sadremomtaz A, Al-Dahmani ZM, Ruiz-Moreno AJ, Monti A, Wang C, Azad T, Bell JC, Doti N, Velasco-Velázquez MA, de Jong D, de Jonge J, Smit J, Dömling A, van Goor H, Groves MR.

DOI   10.1021/acs.jmedchem.1c00477