To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.
General Information
DRAVP ID DRAVPe01991
Peptide Name K5-66
Sequence GELGRLVYLLDGPGYDPIHCSLAYGDASTLVVF
Sequence Length 33
UniProt ID No entry found
Source Synthetic construct
Activity Information
Target Organism HCV
Assay FRET assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity
Binding Target virus replication
Mechanism inhibitory peptides (IPs) capping the active site and binding via a novel "tyrosine" finger at an alternative NS3-4A site that is of particular interest。
Structure Information
PDB ID None
Predicted Structure Download No predicted structure available
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C161H244N38O48S
Absent amino acids KMNQW
Common amino acids L
Mass 3511.99
Pl 4.22
Basic residues 2
Acidic residues 4
Hydrophobic residues 13
Net charge -2
Boman Index -320
Hydrophobicity 47.58
Aliphatic Index 115.15
Half Life
Extinction Coefficient cystines 4470
Absorbance 280nm 139.69
Polar residues 12
Literature Information
Literature 1
Title High affinity peptide inhibitors of the hepatitis C virus NS3-4A protease refractory to common resistant mutants.
Pubmed ID 22965230
Reference J Biol Chem. 2012 Nov 9;287(46):39224-32.
Author Kugler J, Schmelz S, Gentzsch J, Haid S, Pollmann E, van den Heuvel J, Franke R, Pietschmann T, Heinz DW, Collins J.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.