DRAVP ID  DRAVPe01991

Peptide Name   K5-66

Sequence  GELGRLVYLLDGPGYDPIHCSLAYGDASTLVVF

Sequence Length  33

UniProt ID  No entry found

Taxon ID  None

Source  Synthetic construct

Validation   Experimentally Validated

Gene Name/ID  Not Available

GenBank  Not Available

Amino Acid position  Not Available

Domain Accession ID  Not Available

Nucleotide sequence ID  Not Available

Molecular Type  Not Available

Chromosomal Position  Not Available

Target Organism  HCV

Assay  FRET assay

Activity 

• [Ref.22965230]hepatitis C virus(HCV): inhibition of NS3–4A activity(IC50=20.7±3.6 nM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

• No cytotoxicity information or data found in the reference(s) presented in this entry

Binding Target  virus replication

Mechanism  inhibitory peptides (IPs) capping the active site and binding via a novel "tyrosine" finger at an alternative NS3-4A site that is of particular interest。

PDB ID  None

Predicted Structure Download  No predicted structure available

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L

Literature 1

Title   High affinity peptide inhibitors of the hepatitis C virus NS3-4A protease refractory to common resistant mutants.

Pubmed ID   22965230

Reference   J Biol Chem. 2012 Nov 9;287(46):39224-32. 

Author   Kugler J, Schmelz S, Gentzsch J, Haid S, Pollmann E, van den Heuvel J, Franke R, Pietschmann T, Heinz DW, Collins J.

DOI   10.1074/jbc.M112.393843