General Information


DRAVP ID  DRAVPe01997

Peptide Name   CP5-46-A

Sequence  GELGRLVYLLDGPGYDPIHCD

Sequence Length  21

UniProt ID  No entry found

Source  Synthetic construct



Activity Information


Target Organism  HCV

Assay  FRET assay

Activity 

  • [Ref.22965230]hepatitis C virus(HCV): inhibition of NS3–4A activity(IC50=124 nM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

  • No cytotoxicity information or data found in the reference(s) presented in this entry

Binding Target  virus replication

Mechanism  inhibitory peptides (IPs) capping the active site and binding via a novel "tyrosine" finger at an alternative NS3-10A site that is of particular interest。



Structure Information


PDB ID  None

Predicted Structure Download  No predicted structure available

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  C103H156N26O32S

Absent amino acids  AFKMNQSTW

Common amino acids  GL

Mass  2302.59

Pl  4.22

Basic residues  2

Acidic residues  4

Hydrophobic residues  6

Net charge  -2

Boman Index  -1915

Hydrophobicity  -12.86

Aliphatic Index  106.67

Half Life 

  •     Mammalian:30 hour
  •     Yeast:>20 hour
  •     E.coli:>10 hour

Extinction Coefficient cystines  2980

Absorbance 280nm  149

Polar residues  7



Literature Information


Literature 1

Title   High affinity peptide inhibitors of the hepatitis C virus NS3-4A protease refractory to common resistant mutants.

Pubmed ID   22965230

Reference   J Biol Chem. 2012 Nov 9;287(46):39224-32. 

Author   Kugler J, Schmelz S, Gentzsch J, Haid S, Pollmann E, van den Heuvel J, Franke R, Pietschmann T, Heinz DW, Collins J.

DOI   10.1074/jbc.M112.393843