DRAVP ID  DRAVPe02000

Peptide Name   peptide 1

Sequence  ELLVTFKNAHAKKQEVVVLG

Sequence Length  20

UniProt ID  No entry found

Source  Synthetic construct

Target Organism  DENV

Assay  Antiviral assays(Cell protection assay, Direct virus inhibition assay, Post-infection assay, Viral attachment assay, Viral entry assay)

Activity  [Ref.36739680]Peptides 1 at 200 μM exhibited cell protection effects against DENV-1 (69.58%) and DENV-4 (59.44%), but lower inhibitory effects were observed against DENV-2 (32.95%) and DENV-3 (12.59%); Peptides 1(200 μM) demonstrated the highest inhibitions of DENV-3 (67.18%) plaque formations; Peptides 1 (200 μM) demonstrated inhibitions of all four DENV serotypes, but much lower inhibitions were observed against DENV-3 at 26.92%.

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

• [Ref.36739680]did not exhibit any significant cytotoxic effects towards Vero cells up to 200 μM.

Binding Target  Not found

Mechanism  No machanism information found in the reference(s) presented in this entry

PDB ID  None

Predicted Structure Download  No predicted structure available

Linear/Cyclic  Linear

N-terminal Modification  Acetylation

C-terminal Modification  Amidation

Other Modification  None

Stereochemistry  L

Literature 1

Title   Development of novel antiviral peptides against dengue serotypes 1-4. 

Pubmed ID   36739680

Reference   Virology. 2023 Mar;580:10-27.

Author   Lee MF, Anasir MI, Poh CL. 

DOI   10.1016/j.virol.2023.01.016