To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.
General Information
DRAVP ID DRAVPe02018
Peptide Name Nk-lysin
Sequence EGVKSKLNIVCNEIGLLKSLCRKFVNSHIW
Sequence Length 30
UniProt ID A0A1P8CXN4
Taxon ID 52904
Source Synthetic Construct
Validation Experimentally Validated
Origin Information
Gene Name/ID SMAX5B_000299
GenBank KU705506.1
Amino Acid position Nkl71-100
Domain Accession ID APD51552.1
Nucleotide sequence ID KU705506
Molecular Type mRNA
Chromosomal Position Not available
Activity Information
Target Organism SVCV
Assay MTT cell-viability assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity
Binding Target Membrane
Mechanism Nkl71-100exerts strong antiviral activity against spring viremia of carp virus (SVCV) by inhibiting not only the binding of viral particles to host cells, but also the fusion of virus and cell membranes, which requires a low pH context. Such antiviral activity seems to be related to the important role that PS plays in these steps of the replication cycle of SVCV, a feature that is shared by other families of virus-comprising members with health and veterinary relevance. Consequently, Nkl71⁻100 is shown as a promising broad-spectrum antiviral candidate. it was observed that Nkl71–100 alters the binding ability of SVCV to cell membranes since virus-cell binding levels significantly decreased in the presence of peptide in comparison to what it is observed in its absence.
Structure Information
PDB ID None
Predicted Structure Download No predicted structure available
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C154H255N43O41S2
Absent amino acids ADQMTOU
Common amino acids LK
Mass 3429.1
Pl 9.31
Basic residues 5
Acidic residues 2
Hydrophobic residues 5
Net charge 3
Boman Index 2.3
Hydrophobicity 0.14
Aliphatic Index 120
Half Life
Extinction Coefficient cystines 5625
Absorbance 280nm 1.64
Polar residues 6
Literature Information
Literature 1
Title Antiviral Activity of a Turbot (Scophthalmus maximus) NK-Lysin Peptide by Inhibition of Low-pH Virus-Induced Membrane Fusion
Pubmed ID 30717094
Reference Marine drugs, 17(2), 87.
Author Falco, A., Medina-Gali, R. M., Poveda, J. A., Bello-Perez, M., Novoa, B., & Encinar, J. A. (2019).
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.