To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.
General Information
DRAVP ID DRAVPe02021
Peptide Name LVLQTM
Sequence LVLQTM
Sequence Length 6
UniProt ID None
Taxon ID None
Source Derived from the very C terminus of the RBM6Δ6 protein
Validation Experimentally Validated
Origin Information
Gene Name/ID RBM6Δ6 protein
GenBank Not Available
Amino Acid position Not Available
Domain Accession ID Not Available
Nucleotide sequence ID Not Available
Molecular Type Not Available
Chromosomal Position Not Available
Activity Information
Target Organism HRVs,EV-71
Assay Not Available
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity No cytotoxicity information found in the reference(s) presented
Binding Target Not Available
Mechanism peptide inhibited the activity of protease 2 A, which plays several essential roles during viral replication, by coupling in the active site of this enzyme. The in vitro assay with A549 cells and the in vivo assay with mice demonstrated viral replication inhibition
Structure Information
PDB ID None
Predicted Structure Download No predicted structure available
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C31H57N7O9S1
Absent amino acids ARNDCEGHIKFPSWYOU
Common amino acids L
Mass 703.9
Pl 5.52
Basic residues 0
Acidic residues 0
Hydrophobic residues 4
Net charge 0
Boman Index 0.8067
Hydrophobicity 1.583
Aliphatic Index 178.33
Half Life
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 2
Literature Information
Literature 1
Title Ex Vivo and In Vivo Inhibition of Human Rhinovirus Replication by a New Pseudosubstrate of Viral 2A Protease;
Pubmed ID 22072773
Reference Journal of virology, 86(2), 691–704;
Author Falah, N., Violot, S., Décimo, D., Berri, F., Foucault-Grunenwald, M. L., Ohlmann, T., Schuffenecker, I., Morfin, F., Lina, B., Riteau, B., & Cortay, J. C. (2012);
Literature 2
Title Blocking human enterovirus 71 replication by targeting viral 2A protease
Pubmed ID 22865380
Reference The Journal of antimicrobial chemotherapy, 67(12), 2865–2869.
Author Falah, N., Montserret, R., Lelogeais, V., Schuffenecker, I., Lina, B., Cortay, J. C., & Violot, S. (2012).
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.