General Information


DRAVP ID  DRAVPe02024

Peptide Name   L-P1

Sequence  NDFRSKT

Sequence Length  7

UniProt ID  None  

Taxon ID  None

Source  Synthetic Construct

Validation   Experimentally Validated



Origin Information


Gene Name/ID  Not Available

GenBank  Not Available

Amino Acid position  Not Available

Domain Accession ID  Not Available

Nucleotide sequence ID  Not Available

Molecular Type  Not Available

Chromosomal Position  Not Available



Activity Information


Target Organism  Influenza,AIV(H9N2)

Assay  Hemagglutination inhibition assay

Activity 

  • [Ref:19680476]Peptide P1:Inhibition of early-stage viral infection independent of virus entry.[Ref:19497129]AIV(H9N2):IC50=100 μM.

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity  No cytotoxicity information found in the reference(s) presented

Binding Target  Membrane

Mechanism  Prevent the viral replication by inhibiting the attachment or entry of the virus into the target cells



Structure Information


PDB ID  None

Predicted Structure Download  No predicted structure available

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  C36H58N12O13

Absent amino acids  ACQEGHILMPWYVOU

Common amino acids  RNDKFST

Mass  866.93

Pl  8.75

Basic residues  2

Acidic residues  1

Hydrophobic residues  0

Net charge  1

Boman Index  1.3714

Hydrophobicity  -2.014

Aliphatic Index  0

Half Life 

  •     Mammalian:1.4 hours
  •     Yeast:3 min
  •     E.coli:>10 hours

Extinction Coefficient cystines  0

Absorbance 280nm  0

Polar residues  7



Literature Information


Literature 1

Title   A novel peptide inhibits the influenza virus replication by preventing the viral attachment to the host cells

Pubmed ID   19680476

Reference    International journal of biological sciences, 5(6), 543–548

Author   Rajik, M., Omar, A. R., Ideris, A., Hassan, S. S., & Yusoff, K. (2009)

DOI   10.7150/ijbs.5.543

Literature 2

Title   Identification and characterisation of a novel anti-viral peptide against avian influenza virus H9N2

Pubmed ID   19497129

Reference   Virology journal, 6, 74.

Author   Rajik, M., Jahanshiri, F., Omar, A. R., Ideris, A., Hassan, S. S., & Yusoff, K. (2009).

DOI   10.1186/1743-422X-6-74