General Information


DRAVP ID  DRAVPe02025

Peptide Name   C18-s2

Sequence  ARLPRTMVHPKPAQP

Sequence Length  15

UniProt ID  No entry found

Taxon ID  None

Source  Synthetic Construct

Validation   Experimentally Validated



Origin Information


Gene Name/ID  Not Available

GenBank  Not Available

Amino Acid position  Not Available

Domain Accession ID  Not Available

Nucleotide sequence ID  Not Available

Molecular Type  Not Available

Chromosomal Position  Not available



Activity Information


Target Organism  Influenza

Assay  Not Available

Activity 

  • [Ref:20476787]C17H35CO-ARLPRTMV-NH2:Inhibition of influenza A/H1N1/Puerto Rico/8/34 virus (IC50=3.0 and 1.9 μM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity  No cytotoxicity information found in the reference(s) presented

Binding Target  Membrane

Mechanism  Not Available



Structure Information


PDB ID  None

Predicted Structure Download  No predicted structure available

Linear/Cyclic  Linear

N-terminal Modification  C17H35CO

C-terminal Modification  Amidation

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  C75H127N25O18S1

Absent amino acids  NDCEGIFSWYOU

Common amino acids  ARP

Mass  1699.05

Pl  12

Basic residues  3

Acidic residues  0

Hydrophobic residues  9

Net charge  3

Boman Index  1.2143

Hydrophobicity  -0.88

Aliphatic Index  58.67

Half Life 

  •     Mammalian:4.4 hours (mammalian reticulocytes, in vitro)
  •     Yeast:>20 hours
  •     E.coli:>10 hours

Extinction Coefficient cystines  0

Absorbance 280nm  0

Polar residues  6



Literature Information


Literature 1

Title   Antiviral Peptides as Anti-Influenza Agents

Pubmed ID   36232735

Reference   International journal of molecular sciences, 23(19), 11433

Author   Agamennone, M., Fantacuzzi, M., Vivenzio, G., Scala, M. C., Campiglia, P., Superti, F., & Sala, M. (2022)

DOI   10.3390/ijms231911433

Literature 2

Title   Sialic acid-mimic peptides as hemagglutinin inhibitors for anti-influenza therapy

Pubmed ID   20476787

Reference   Journal of medicinal chemistry, 53(11), 4441–4449

Author   Matsubara, T., Onishi, A., Saito, T., Shimada, A., Inoue, H., Taki, T., Nagata, K., Okahata, Y., & Sato, T. (2010).

DOI   10.1021/jm1002183