General Information


DRAVP ID  DRAVPe02030

Peptide Name   P9

Sequence  CANLLLQYGSFCTQLNRALSGIA

Sequence Length  23

UniProt ID  P59594 

Taxon ID  694009  

Source  synthetic Construct (Derived from SARS-CoV: 694009))

Validation   Experimentally Validated



Origin Information


Gene Name/ID  S2 (918758),

GenBank  AY278741.1

Amino Acid position  731-753

Domain Accession ID  pfam01601 cd22378 

Nucleotide sequence ID  AY278741 

Molecular Type  Genomic RNA

Chromosomal Position  N/A



Activity Information


Target Organism  SARS-CoV

Assay  Syncytia inhibition assay

Activity  Not Avaialble

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity  No cytotoxicity information found in the reference(s) presented

Binding Target  Spike Protein

Mechanism  P9 themselves can markedly inhibit syncytia formation



Structure Information


PDB ID  7SG4 

Predicted Structure Download  No predicted structure available

Linear/Cyclic  Cyclic

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  C107H174N30O32S2

Absent amino acids  DEHKMPVW

Common amino acids  ALCGNQS

Mass  2456.86

Pl  6.72

Basic residues  1

Acidic residues  0

Hydrophobic residues 

Net charge  1

Boman Index 

Hydrophobicity  0.6

Aliphatic Index  114.78

Half Life 

  •     Mammalian:1.2 hours
  •     Yeast:>20 hours
  •     E.coli:>10 hours

Extinction Coefficient cystines  1490

Absorbance 280nm  0.606

Polar residues 



Literature Information


Literature 1

Title   FEBS letters, 579(10), 2130–2136.

Pubmed ID   15811330

Reference   Synthetic peptides derived from SARS coronavirus S protein with diagnostic and therapeutic potential

Author   Lu, W., Wu, X. D., Shi, M. D., Yang, R. F., He, Y. Y., Bian, C., Shi, T. L., Yang, S., Zhu, X. L., Jiang, W. H., Li, Y. X., Yan, L. C., Ji, Y. Y., Lin, Y., Lin, G. M., Tian, L., Wang, J., Wang, H. X., Xie, Y. H., Pei, G., … Sun, B. (2005).

DOI   10.1016/j.febslet.2005.02.070