To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.
General Information
DRAVP ID DRAVPe02031
Peptide Name VIR-576
Sequence LEAIPCSIPPEFLFGKPFVFLEAIPCSIPPEFLFGKPFVF
Sequence Length 40
UniProt ID No entry found
Taxon ID None
Source Synthetic Construct
Validation Experimentally Validated
Origin Information
Gene Name/ID E2 Protein
GenBank Not Available
Amino Acid position 29 -72
Domain Accession ID cd02056 cd02056
Nucleotide sequence ID Not Available
Molecular Type Not Available
Chromosomal Position Not Available
Activity Information
Target Organism HIV-1
Assay inhibition assay
Activity Not Avaialble
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity No cytotoxicity information found in the reference(s) presented
Binding Target Spike Protein
Mechanism Not Available
Structure Information
Predicted Structure Download No predicted structure available
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C224H324N42O51S2
Absent amino acids RNDQHMTWYOU
Common amino acids EILFP
Mass 4485.41
Pl 4.49
Basic residues 2
Acidic residues 4
Hydrophobic residues
Net charge -2
Boman Index
Hydrophobicity 0.89
Aliphatic Index 97.5
Half Life
Extinction Coefficient cystines 125
Absorbance 280nm 0.028
Polar residues
Literature Information
Literature 1
Title Peptides derived from a distinct region of GB virus C glycoprotein E2 mediate strain-specific HIV-1 entry inhibition
Pubmed ID 21543477
Reference Journal of virology, 85(14), 7037–7047
Author Koedel, Y., Eissmann, K., Wend, H., Fleckenstein, B., & Reil, H. (2011)
Literature 2
Title Discovery and optimization of a natural HIV-1 entry inhibitor targeting the gp41 fusion peptide
Pubmed ID 17448989
Reference Cell, 129(2), 263–275
Author Münch, J., Ständker, L., Adermann, K., Schulz, A., Schindler, M., Chinnadurai, R., Pöhlmann, S., Chaipan, C., Biet, T., Peters, T., Meyer, B.,
DOI 10.1016/j.cell.2007.02.042
Literature 3
Title Short-term monotherapy in HIV-infected patients with a virus entry inhibitor against the gp41 fusion peptide.
Pubmed ID 21178138
Reference Science translational medicine, 2(63), 63re3.
Author Wilhelm, D., Lu, H., Jing, W., Jiang, S., Forssmann, W. G., & Kirchhoff, F.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.