General Information

General Information

DRAVP ID DRAVPe02036

Peptide Name TLTTKLY

Sequence TLTTKLY

Sequence Length 7

UniProt ID No entry found

Taxon ID None

Source Synthetic Construct

Validation Experimentally Validated

Origin Information

Gene Name/ID Not Available

GenBank Not Available

Amino Acid position Not available

Domain Accession ID Not Available

Nucleotide sequence ID Not Available

Molecular Type Not Available

Chromosomal Position Not Available

Activity Information

Target Organism NDV, IBV

Assay competition assay

Activity

[Ref. 12021868]NDV: Inhibition of hemolytic activity and viral propagation in embryonated chicken eggs. Inhibition of phage binding with the same sequence.

Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity No cytotoxicity information found in the reference(s) presented

Binding Target Spike Protein

Mechanism Entry inhibition

Structure Information

PDB ID None

Predicted Structure Download No predicted structure available

Linear/Cyclic Linear

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Stereochemistry L

Physicochemical Information

Formula C39H66N8O12

Absent amino acids ARNDCQEGHIMFPSWVOu

Common amino acids LT

Mass 839

Pl 8.26

Basic residues 1

Acidic residues 0

Hydrophobic residues 5

Net charge 1

Boman Index

Hydrophobicity 0.043

Aliphatic Index 111.43

Half Life

Mammalian:7.2 hours
Yeast:>20 hours
E.coli:>10 hours

Extinction Coefficient cystines 1490

Absorbance 280nm 1.776

Polar residues 2

Literature Information

Literature 1

Title Novel peptides that inhibit the propagation of Newcastle disease virus;

Pubmed ID 12021868

Reference Archives of virology, 147(5), 981–993;

Author Ramanujam, P., Tan, W. S., Nathan, S., & Yusoff, K. (2002);

DOI 10.1007/s00705-001-0778-y;

Literature 2

Title Structural analysis of peptides that interact with Newcastle disease virus

Pubmed ID 16377031

Reference Peptides, 27(6), 1217–1225.

Author Chia, S. L., Tan, W. S., Shaari, K., Abdul Rahman, N., Yusoff, K., & Satyanarayanajois, S. D. (2006).

DOI 10.1016/j.peptides.2005.11.018