DRAVP ID  DRAVPe02040

Peptide Name   Surfactin

Sequence  L-Glu- L-Val- D-Leu- L-Ala- L-Asp- D-Leu- L-Val

Sequence Length  6

UniProt ID  No entry found

Taxon ID  None

Source  Synthetic Construct(derived from Bacillus subtilis)

Validation   Experimentally Validated

Gene Name/ID  Not Available

GenBank  Not Available

Amino Acid position  Not Available

Domain Accession ID  Not Available

Nucleotide sequence ID  Not Available

Molecular Type  Not Available

Chromosomal Position  Not Available

Target Organism  PEDV

Assay  Plaque reduction assay

Activity 

• [Ref:30973929] PEDV; EC50 11.4 ± 0.7 μg/ml

Hemolytic Activity 

• [Ref:30973929] Low Hemolytic Activity

Cytotoxicity 

• [Ref:30973929] CC50:45.9 ± 0.9 μg/ml

Binding Target  Membrane

Mechanism  surfactin exerts its antiviral effects by inhibiting viral membrane fusion. Membrane fusion between the viral envelope and the cell membrane is essential for enveloped viruses to invade host cells. Surfactin can act directly on virus particles by insertion into the viral envelopes’ lipid bilayer and thereby reduce the membrane fusion rate.

PDB ID  None

Predicted Structure Download  No predicted structure available

Linear/Cyclic  Linear

N-terminal Modification  palmitoylation

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L

Literature 1

Title   Synthetic surfactin analogues have improved anti-PEDV properties

Pubmed ID   30973929

Reference   PloS one, 14(4), e0215227.

Author   Yuan, L., Zhang, S., Peng, J., Li, Y., & Yang, Q. (2019).

DOI   10.1371/journal.pone.0215227