General Information


DRAVP ID  DRAVPe02045

Peptide Name   SLP5

Sequence  L-Glu- L-Val- D-Leu- L-Asp- D-Leu

Sequence Length  5

UniProt ID  No entry found

Taxon ID  None

Source  Synthetic Construct(derived from Bacillus subtilis)

Validation   Experimentally Validated



Origin Information


Gene Name/ID  Not Available

GenBank  Not Available

Amino Acid position  Not Available

Domain Accession ID  Not Available

Nucleotide sequence ID  Not Available

Molecular Type  Not Available

Chromosomal Position  Not Available



Activity Information


Target Organism  PEDV

Assay  Plaque reduction assay

Activity 

  • [Ref:30973929]PEDV:EC50 16.5 ± 0.6 μg/ml

Hemolytic Activity 

  • [Ref:30973929] hemolytic activity is reduced

Cytotoxicity 

  • [Ref:30973929] CC50: 847.2 ± 124.9 μg/ml

Binding Target  Membrane

Mechanism  Inhibiting viral membrane fusion



Structure Information


PDB ID  None

Predicted Structure Download  No predicted structure available

Linear/Cyclic  Linear

N-terminal Modification  palmitoylation

C-terminal Modification  Carboxylation

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  C26H45N5O10

Absent amino acids  ARNCQGHIKMFPSTWYOU

Common amino acids  L

Mass  587.67

Pl  3.67

Basic residues  0

Acidic residues  2

Hydrophobic residues  3

Net charge  -2

Boman Index  0.8133

Hydrophobicity  0.96

Aliphatic Index  214

Half Life 

  •     Mammalian:1 hour
  •     Yeast:30 mins
  •     E.coli:>10 hours

Extinction Coefficient cystines  0

Absorbance 280nm  0

Polar residues  2



Literature Information


Literature 1

Title   Synthetic surfactin analogues have improved anti-PEDV properties

Pubmed ID   30973929

Reference   PloS one, 14(4), e0215227.

Author   Yuan, L., Zhang, S., Peng, J., Li, Y., & Yang, Q. (2019).

DOI   10.1371/journal.pone.0215232