General Information

General Information

DRAVP ID DRAVPe02061

Peptide Name SP-10-1

Sequence CDIPIGAGICAS

Sequence Length 12

UniProt ID P26436 P59594

Taxon ID 694009

Source Synthetic Construct(derived from SARS-CoV S protein)

Validation Experimentally Validated

Origin Information

Gene Name/ID S2(MAX5B_000299)

GenBank AY278741.1

Amino Acid position 648–659

Domain Accession ID Not Available

Nucleotide sequence ID CM000673.2 AY274119.3

Molecular Type Genomic RNA

Chromosomal Position Chromosome:21,492 - 25,259

Activity Information

Target Organism SARS-CoV

Assay ELISA

Activity

[Ref:16337697] SARS-CoV IC50= >20µg/mL

Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity No cytotoxicity information found in the reference(s) presented

Binding Target ACE2

Mechanism Acts as a viral fusion peptide which is unmasked following S2 cleavage occurring upon virus endocytosis.

Structure Information

PDB ID 1WNC 1ZV7

Predicted Structure Download No predicted structure available

Linear/Cyclic Linear

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Stereochemistry L

Physicochemical Information

Formula C46H78N12O16S2

Absent amino acids RNQEHLKMFTWYVOU

Common amino acids I

Mass 1119.32

Pl 3.8

Basic residues 0

Acidic residues 1

Hydrophobic residues 9

Net charge -1

Boman Index 0.5877

Hydrophobicity 1.283

Aliphatic Index 114.17

Half Life

Mammalian:1.2 hours
Yeast:>20 hours
E.coli:>10 hours

Extinction Coefficient cystines 0

Absorbance 280nm 0

Polar residues 9

Literature Information

Literature 1

Title Design and biological activities of novel inhibitory peptides for SARS-CoV spike protein and angiotensin-converting enzyme 2 interaction

Pubmed ID 16337697

Reference Antiviral research, 69(2), 70–76.

Author Ho, T. Y., Wu, S. L., Chen, J. C., Wei, Y. C., Cheng, S. E., Chang, Y. H., Liu, H. J., & Hsiang, C. Y. (2006)

DOI 10.1016/j.antiviral.2005.10.002