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General Information
DRAVP ID DRAVPe02062
Peptide Name SP-10-2
Sequence YHTVSLLRSTSQ
Sequence Length 12
Taxon ID 694009
Source Synthetic Construct(derived from SARS-CoV S protein)
Validation Experimentally Validated
Origin Information
Gene Name/ID S2(MAX5B_000299)
GenBank AY278741.2
Amino Acid position 660–671
Domain Accession ID Not Available
Nucleotide sequence ID CM000673.2 AY274119.4
Molecular Type Genomic RNA
Chromosomal Position Chromosome:21,492 - 25,259
Activity Information
Target Organism SARS-CoV
Assay ELISA
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity No cytotoxicity information found in the reference(s) presented
Binding Target ACE2
Mechanism Acts as a viral fusion peptide which is unmasked following S2 cleavage occurring upon virus endocytosis.
Structure Information
Predicted Structure Download No predicted structure available
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C60H98N18O20
Absent amino acids ANDCEGIKMFPWOU
Common amino acids S
Mass 1391.55
Pl 8.75
Basic residues 1
Acidic residues 0
Hydrophobic residues 11
Net charge 1
Boman Index 0.8833
Hydrophobicity -0.375
Aliphatic Index 89.17
Half Life
Extinction Coefficient cystines 1490
Absorbance 280nm 1.071
Polar residues 11
Literature Information
Literature 1
Title Design and biological activities of novel inhibitory peptides for SARS-CoV spike protein and angiotensin-converting enzyme 2 interaction
Pubmed ID 16337697
Reference Antiviral research, 69(2), 70–76.
Author Ho, T. Y., Wu, S. L., Chen, J. C., Wei, Y. C., Cheng, S. E., Chang, Y. H., Liu, H. J., & Hsiang, C. Y. (2006)
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.