To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.
General Information
DRAVP ID DRAVPe02064
Peptide Name SP-10-4
Sequence KSIVAYTMSLGA
Sequence Length 12
Taxon ID 694009
Source Synthetic Construct(derived from SARS-CoV S protein)
Validation Experimentally Validated
Origin Information
Gene Name/ID S2(MAX5B_000299)
GenBank AY278741.5
Amino Acid position 672–683
Domain Accession ID Not Available
Nucleotide sequence ID CM000673.2 AY274119.7
Molecular Type Genomic RNA
Chromosomal Position Chromosome:21,492 - 25,259
Activity Information
Target Organism SARS-CoV
Assay ELISA
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity No cytotoxicity information found in the reference(s) presented
Binding Target ACE2
Mechanism Acts as a viral fusion peptide which is unmasked following S2 cleavage occurring upon virus endocytosis.
Structure Information
Predicted Structure Download No predicted structure available
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C55H93N13O17S1
Absent amino acids RNDCQEHFPWOU
Common amino acids AS
Mass 1240.48
Pl 8.59
Basic residues 1
Acidic residues 0
Hydrophobic residues 12
Net charge 1
Boman Index 0.8667
Hydrophobicity 0.842
Aliphatic Index 105.83
Half Life
Extinction Coefficient cystines 1490
Absorbance 280nm 1.201
Polar residues 12
Literature Information
Literature 1
Title Design and biological activities of novel inhibitory peptides for SARS-CoV spike protein and angiotensin-converting enzyme 2 interaction
Pubmed ID 16337697
Reference Antiviral research, 69(2), 70–76.
Author Ho, T. Y., Wu, S. L., Chen, J. C., Wei, Y. C., Cheng, S. E., Chang, Y. H., Liu, H. J., & Hsiang, C. Y. (2006)
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.