DRAVP ID  DRAVPe02067

Peptide Name   BMAP-27

Sequence  GRFKRFRKKFKKLFKKLSPVIPLLHLG

Sequence Length  27

UniProt ID  P54228 

Taxon ID  9913 

Source  Cattle, Bos taurus

Validation   Experimentally Validated

Gene Name/ID  CATHL6(317651)

GenBank  X97608.1

Amino Acid position  132-158

Domain Accession ID  Not Available

Nucleotide sequence ID  X97608 

Molecular Type  mRNA

Chromosomal Position  Chromosome 22(NC_037349.1 (51663351..51665275, complement))

Target Organism  HIV-1

Assay  Inhibition assay

Activity 

• [Ref:18591279]HIV-1: BMAP-27 blocks HIV-1 infection

Hemolytic Activity 

• [Ref:18591279]HC50>100 uM to hRBC (3.5% hemolysis at 3 uM; 32.7% hemolysis at 100 uM), but not hemo.lytic to bovine RBC even at 100 uM. Thus, hemolysis is related to cell sources, indicating the need

Cytotoxicity  No cytotoxicity information found in the reference(s) presented

Binding Target  Membrane

Mechanism  inhibit viral replication

PDB ID  2KET 

Predicted Structure Download  No predicted structure available

Linear/Cyclic  Linear

N-terminal Modification  Carboxylation

C-terminal Modification  Amidation

Other Modification   a 26mer was mad with a hydrophobic tail

Stereochemistry  L

Literature 1

Title   Anti-human immunodeficiency virus type 1 activities of antimicrobial peptides derived from human and bovine cathelicidins

Pubmed ID   18591279

Reference   Antimicrobial agents and chemotherapy, 52(9), 3438–3440.

Author   Wang, G., Watson, K. M., & Buckheit, R. W., Jr (2008).

DOI   10.1128/AAC.00452-08