To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.
General Information
DRAVP ID DRAVPe02068
Peptide Name Aurein 1.2
Sequence GLFDIIKKIAESF
Sequence Length 13
UniProt ID P82387
Taxon ID 116057
Source Southern bell frog Litoria aurea and Litoria raniformis, Australia
Validation Experimentally Validated
Origin Information
Gene Name/ID Not Available
GenBank Not Available
Amino Acid position 1to13
Domain Accession ID Not Available
Nucleotide sequence ID Not Available
Molecular Type Not Available
Chromosomal Position Not Available
Activity Information
Target Organism HIV-1
Assay Inhibition assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity No cytotoxicity information found in the reference(s) presented
Binding Target Membrane
Mechanism Aurein 1.2 interacts with membranes and can induce curvature and disintegration, which is crucial for its antimicrobial activity .This mechanism could theoretically be effective against viral membranes, although this has not been extensively studied in the context of HIV
Structure Information
PDB ID 1VM5
Predicted Structure Download No predicted structure available
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification F13
Stereochemistry L
Physicochemical Information
Formula C71H113N15O19
Absent amino acids RNCQHMPTWYVOU
Common amino acids I
Mass 1480.77
Pl 6.07
Basic residues 2
Acidic residues 2
Hydrophobic residues 10
Net charge 0
Boman Index 0.12
Hydrophobicity 0.669
Aliphatic Index 127.69
Half Life
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 13
Literature Information
Literature 1
Title Identification of novel human immunodeficiency virus type 1-inhibitory peptides based on the antimicrobial peptide database
Pubmed ID 20086159
Reference Antimicrobial agents and chemotherapy, 54(3), 1343–1346
Author Wang, G., Watson, K. M., Peterkofsky, A., & Buckheit, R. W., Jr (2010)
Literature 2
Title Antimicrobial peptides melittin and cecropin inhibit replication of human immunodeficiency virus 1 by suppressing viral gene expression
Pubmed ID 9568968
Reference The Journal of general virology, 79 ( Pt 4), 731–740
Author Wachinger, M., Kleinschmidt, A., Winder, D., von Pechmann, N., Ludvigsen, A., Neumann, M., Holle, R., Salmons, B., Erfle, V., & Brack-Werner, R. (1998)
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.