General Information

General Information

DRAVP ID DRAVPe02074

Peptide Name Caerin 1.4

Sequence GLLSSLSSVAKHVLPHVVPVIAEHL

Sequence Length 25

UniProt ID P62544 P62545

Taxon ID 30344

Source Australian frog Litoria caerula

Validation Experimentally Validated

Origin Information

Gene Name/ID Not Available

GenBank Not Available

Amino Acid position 1to25

Domain Accession ID Not Available

Nucleotide sequence ID Not Available

Molecular Type Not Available

Chromosomal Position Not Available

Activity Information

Target Organism HIV

Assay HIV infection and cell viability assay.

Activity

[Ref:26026377]HIV: Less effective inhibitor of infection

Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity

[Ref:26026377]Non-toxic or only modestly toxic at the concentrations tested

Binding Target Cell Membrane

Mechanism The disruption of the viral envelope and release p24 core protein

Structure Information

PDB ID None

Predicted Structure Download No predicted structure available

Linear/Cyclic Linear

N-terminal Modification Free

C-terminal Modification Amination

Other Modification None

Stereochemistry L

Physicochemical Information

Formula C120H200N32O32

Absent amino acids RNDCKMFTWYOU

Common amino acids V

Mass 2603.1

Pl 7.02

Basic residues 1

Acidic residues 1

Hydrophobic residues 16

Net charge 0

Boman Index -0.57

Hydrophobicity 0.972

Aliphatic Index 159.6

Half Life

Mammalian:30 hours
Yeast:>20 hours
E.coli:>10 hours

Extinction Coefficient cystines 0

Absorbance 280nm 0

Polar residues 22

Literature Information

Literature 1

Title Inhibition of HIV infection by caerin 1 antimicrobial peptides

Pubmed ID 26026377

Reference Peptides, 71, 296–303.

Author VanCompernolle, S., Smith, P. B., Bowie, J. H., Tyler, M. J., Unutmaz, D., & Rollins-Smith, L. A. (2015).

DOI 10.1016/j.peptides.2015.05.004