To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.
General Information
DRAVP ID DRAVPe02075
Peptide Name Caerin 4.1
Sequence GLWQKIKSAAGDLASGIVEGIKS
Sequence Length 23
UniProt ID P56242
Taxon ID 30344
Source Green tree frog Litoria caerula, Australia
Validation Experimentally Validated
Origin Information
Gene Name/ID Not Available
GenBank Not Available
Amino Acid position 1to23
Domain Accession ID Not Available
Nucleotide sequence ID Not Available
Molecular Type Not Available
Chromosomal Position Not Available
Activity Information
Target Organism HIV
Assay HIV infection and cell viability assay.
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity
Binding Target T cells
Mechanism inhibit HIV infection at significantly lower concentrations than those required to affect the viability of the T cells.
Structure Information
PDB ID None
Predicted Structure Download No predicted structure available
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Amination
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C104H174N28O32
Absent amino acids RNCHMFPTYOU
Common amino acids G
Mass 2328.69
Pl 8.5
Basic residues 3
Acidic residues 2
Hydrophobic residues 16
Net charge 1
Boman Index 0.33
Hydrophobicity 0.157
Aliphatic Index 110.43
Half Life
Extinction Coefficient cystines 5500
Absorbance 280nm 2.362
Polar residues 22
Literature Information
Literature 1
Title Antimicrobial peptides from amphibian skin potently inhibit human immunodeficiency virus infection and transfer of virus from dendritic cells to T cells
Pubmed ID 16140737
Reference Journal of virology, 79(18), 11598–11606.
Author VanCompernolle, S. E., Taylor, R. J., Oswald-Richter, K., Jiang, J., Youree, B. E., Bowie, J. H., Tyler, M. J., Conlon, J. M., Wade, D., Aiken, C., Dermody, T. S., KewalRamani, V. N., Rollins-Smith, L. A., & Unutmaz, D. (2005).
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.