General Information


DRAVP ID  DRAVPe02079

Peptide Name   Coconut antifungal peptide

Sequence  EQCREEEDDR

Sequence Length  10

UniProt ID  None  

Taxon ID  None 

Source  Cocos nucifera

Validation   Experimentally Validated



Origin Information


Gene Name/ID  Not Available

GenBank  Not Available

Amino Acid position  Not Available

Domain Accession ID  Not Available

Nucleotide sequence ID  Not Available

Molecular Type  Not Available

Chromosomal Position  Not Available



Activity Information


Target Organism  HIV-1

Assay  Not Found

Activity 

  • [Ref:16308082]HIV-1 reverse transcriptase: IC50 = 52.5 µM; Inhibition at 8 and 80 µM coconut antifungal peptide = 20.1% and 68.4%, respectively.

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity  No cytotoxicity information found in the reference(s) presented

Binding Target  Not Found

Mechanism   It lowered the HIV-1 reverse transcriptase activity



Structure Information


PDB ID  None

Predicted Structure Download  No predicted structure available

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  ANGHILKMNFPSTWYVOU

Absent amino acids 

Common amino acids  E

Mass  1308.3

Pl  4.08

Basic residues  2

Acidic residues  6

Hydrophobic residues  0

Net charge  -4

Boman Index  7.87

Hydrophobicity  -3.1

Aliphatic Index  0

Half Life 

  •     Mammalian:1 hour
  •     Yeast:30 min
  •     E.coli:>10 hours

Extinction Coefficient cystines  0

Absorbance 280nm  0

Polar residues  10



Literature Information


Literature 1

Title   An antifungal peptide from the coconut

Pubmed ID   16308082

Reference   Peptides, 26(12), 2392–2396

Author   Wang, H. X., & Ng, T. B. (2005)

DOI   10.1016/j.peptides.2005.05.009