General Information


DRAVP ID  DRAVPe02080

Peptide Name   Cycloviolacin VY1

Sequence  CGESCVFIPCITTVLGCSCSIKVCYKNGSIP

Sequence Length  31

UniProt ID  None  

Taxon ID  None 

Source  Viola yedoensis

Validation   Experimentally Validated



Origin Information


Gene Name/ID  Not Available

GenBank  Not Available

Amino Acid position  Not Available

Domain Accession ID  Not Available

Nucleotide sequence ID  Not Available

Molecular Type  Not Available

Chromosomal Position  Not Available



Activity Information


Target Organism  IAV

Assay  In vitro assay

Activity 

  • [Ref:25212039]Influenza A virus (H1N1): IC50 = 2.27 µg/mL.

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity  No cytotoxicity information found in the reference(s) presented

Binding Target  Not Found

Mechanism  Not Found



Structure Information


PDB ID  None

Predicted Structure Download  No predicted structure available

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  C138H226N34O42S6

Absent amino acids  ARDQMWOU

Common amino acids  C

Mass  3225.88

Pl  7.77

Basic residues  2

Acidic residues  1

Hydrophobic residues  18

Net charge  1

Boman Index  -0.21

Hydrophobicity  0.874

Aliphatic Index  90.97

Half Life 

  •     Mammalian:1.2 hours
  •     Yeast:>20 hours
  •     E.coli:>10 hours

Extinction Coefficient cystines  1490

Absorbance 280nm  0.462

Polar residues  24



Literature Information


Literature 1

Title   [A cyclotide against influenza A H1N1 virus from Viola yedoensis]

Pubmed ID   25212039

Reference   Yao xue xue bao = Acta pharmaceutica Sinica, 49(6), 905–912.

Author   Liu, M. Z., Yang, Y., Zhang, S. X., Tang, L., Wang, H. M., Chen, C. J., Shen, Z. F., Cheng, K. D., Kong, J. Q., & Wang, W. (2014).

DOI   Not Available