To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.
General Information
DRAVP ID DRAVPe02081
Peptide Name Dahlein 5.6
Sequence GLLASLGKVFGGYLAEKLKPK
Sequence Length 21
UniProt ID P84272
Taxon ID 299727
Source Litoria dahlii, Australia
Validation Experimentally Validated
Origin Information
Gene Name/ID Not Available
GenBank Not Available
Amino Acid position 1to21
Domain Accession ID Not Available
Nucleotide sequence ID Not Available
Molecular Type Not Available
Chromosomal Position Not Available
Activity Information
Target Organism HIV
Assay HIV infection and cell viability assay.
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity No cytotoxicity information found in the reference(s) presented
Binding Target Cell Membrane
Mechanism inhibit HIV infection at significantly lower concentrations than those required to affect the viability of the T cells.
Structure Information
PDB ID None
Predicted Structure Download No predicted structure available
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C104H173N25O26
Absent amino acids RNDCQHIMTWOU
Common amino acids L
Mass 2189.67
Pl 9.83
Basic residues 4
Acidic residues 1
Hydrophobic residues 16
Net charge 3
Boman Index -0.3
Hydrophobicity 0.248
Aliphatic Index 116.19
Half Life
Extinction Coefficient cystines 1490
Absorbance 280nm 0.68
Polar residues 22
Literature Information
Literature 1
Title Antimicrobial peptides from amphibian skin potently inhibit human immunodeficiency virus infection and transfer of virus from dendritic cells to T cells
Pubmed ID 16140737
Reference Journal of virology, 79(18), 11598–11606.
Author VanCompernolle, S. E., Taylor, R. J., Oswald-Richter, K., Jiang, J., Youree, B. E., Bowie, J. H., Tyler, M. J., Conlon, J. M., Wade, D., Aiken, C., Dermody, T. S., KewalRamani, V. N., Rollins-Smith, L. A., & Unutmaz, D. (2005).
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.