General Information


DRAVP ID  DRAVPe02083

Peptide Name   PEP 19-8D

Sequence  GFWFKGKWRFKKYRGGRYKKFRWKGKFWFG

Sequence Length  30

UniProt ID  None  

Taxon ID  None 

Source  Synthetic construct

Validation   Experimentally Validated



Origin Information


Gene Name/ID  Not Available

GenBank  Not Available

Amino Acid position  Not Available

Domain Accession ID  Not Available

Nucleotide sequence ID  Not Available

Molecular Type  Not Available

Chromosomal Position  Not Available



Activity Information


Target Organism  H7N7,H3N2,H1N2

Assay  Hemagglutination assay

Activity 

  • [Ref:24486207]Influenza virus: SALPs PEP 19-8D inhibited virus hemagglutination up to 75% depending on virus subtype and dilution

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity  No cytotoxicity information found in the reference(s) presented

Binding Target  Membrane

Mechanism  Inhibit Virus Attachment and Virus-Cell Membrane Fusion



Structure Information


PDB ID  None

Predicted Structure Download  No predicted structure available

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  C200H276N54O33

Absent amino acids  ANDCQEHILMPSTVOU

Common amino acids  RGKFWY

Mass  3964.73

Pl  11.64

Basic residues  12

Acidic residues  0

Hydrophobic residues  17

Net charge  12

Boman Index  1.1

Hydrophobicity  -1.367

Aliphatic Index  0

Half Life 

  •     Mammalian:30 hours
  •     Yeast:>20 hours (yeast, in
  •     E.coli:>10 hours

Extinction Coefficient cystines  24980

Absorbance 280nm  6.301

Polar residues  10



Literature Information


Literature 1

Title   A new class of synthetic anti-lipopolysaccharide peptides inhibits influenza A virus replication by blocking cellular attachment

Pubmed ID   24486207

Reference   Antiviral research, 104, 23–33. 

Author   Hoffmann, J., Schneider, C., Heinbockel, L., Brandenburg, K., Reimer, R., & Gabriel, G. (2014). 

DOI   10.1016/j.antiviral.2014.01.016