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General Information
DRAVP ID DRAVPe02084
Peptide Name Mastoparan-MO
Sequence FLPIIINLKALAALAKKIL
Sequence Length 19
UniProt ID P01514
Taxon ID 7452
Source Venom, Vespula lewisii
Validation Experimentally Validated
Origin Information
Gene Name/ID Not Available
GenBank Not Available
Amino Acid position Not Available
Domain Accession ID Not Available
Nucleotide sequence ID Not Available
Molecular Type Not Available
Chromosomal Position Not Available
Activity Information
Target Organism HSV-1
Assay Plaque Assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity
Binding Target Membrane
Mechanism Mastoparan-MO exhibited over 80% HSV-1 inhibition, with up to 99% viral replication inhibition, particularly in the early infection stages.
Structure Information
PDB ID 6DUU)
Predicted Structure Download No predicted structure available
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C102H179N23O21
Absent amino acids RDCEQGHMSTWYVOU
Common amino acids L
Mass 2063.68
Pl 10.03
Basic residues 3
Acidic residues 0
Hydrophobic residues 15
Net charge 3
Boman Index 0.8211
Hydrophobicity 1.589
Aliphatic Index 205.79
Half Life
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 4
Literature Information
Literature 1
Title Antiviral Activities of Mastoparan-L-Derived Peptides against Human Alphaherpesvirus 1
Pubmed ID 38932240
Reference Viruses. 2024 Jun 12;16(6)
Author Vilas Boas LCP, Buccini DF, Berlanda RLA, Santos BPO, Maximiano MR, Lião LM, Gonçalves S, Santos NC, Franco OL.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.