To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.
General Information
DRAVP ID DRAVPe02087
Peptide Name PB1731–757
Sequence ESGRIKKEEFAEIMKICSTIEELGRQK
Sequence Length 27
UniProt ID Q9Q0V0
Source Synthetic construct (derived from the C-terminus of PB1)
Validation Experimentally Validated
Origin Information
Gene Name/ID PB1(3654616)
GenBank AAD51923.1
Amino Acid position 731-757
Domain Accession ID Not Available
Nucleotide sequence ID AF144301.1
Molecular Type Genomic RNA
Chromosomal Position Chromosome:25 - 2,298
Activity Information
Target Organism IAV(H5N1)
Assay BiFC disruption assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity No cytotoxicity information found in the reference(s) presented
Binding Target Not given
Mechanism PB1(731-757) is capable of inhibiting viral polymerase activity and viral replication.
Structure Information
Predicted Structure Download No predicted structure available
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C135H230N38O44S2
Absent amino acids NDHPWYVOU
Common amino acids E
Mass 3153.66
Pl 6.46
Basic residues 6
Acidic residues 6
Hydrophobic residues 9
Net charge 0
Boman Index 2.7
Hydrophobicity -0.793
Aliphatic Index 75.93
Half Life
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 2
Literature Information
Literature 1
Title A peptide derived from the C-terminus of PB1 inhibits influenza virus replication by interfering with viral polymerase assembly
Pubmed ID 23279951
Reference The FEBS journal, 280(4), 1139–1149
Author Li, C., Ba, Q., Wu, A., Zhang, H., Deng, T., & Jiang, T. (2013)
Literature 2
Title Influenza A virus entry inhibitors targeting the hemagglutinin
Pubmed ID 23340380
Reference Viruses, 5(1), 352–373
Author Jie Yang 1, Minmin Li, Xintian Shen, Shuwen Liu
DOI 10.3390/v5010352
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.