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General Information
DRAVP ID DRAVPe02088
Peptide Name HNP-1
Sequence CYCRIPACIAGERRYGTCIYQGRLWAFCC
Sequence Length 29
UniProt ID P59665
Taxon ID 9606
Source Synthetic construct
Other Link DRAVPe00300
Validation Experimentally Validated
Origin Information
Gene Name/ID DEFA1; DEFA1B
GenBank M21130.1
Amino Acid position 59-74
Domain Accession ID pfam00323 smart00048
Nucleotide sequence ID CM000670.2
Molecular Type mRNA
Chromosomal Position Chromosome 8:6996766-6999198
Activity Information
Target Organism IAV(H3N2)
Assay Antiviral activity assay.
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity No cytotoxicity information found in the reference(s) presented
Binding Target Not given
Mechanism HNP-1 treatment inhibited protein kinase C (PKC) activation in infected cells, suggesting the involvement of the PKC pathway
Structure Information
Predicted Structure Download No predicted structure available
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Stereochemistry L
Physicochemical Information
Formula
Absent amino acids
Common amino acids
Mass
Pl
Basic residues
Acidic residues
Hydrophobic residues
Net charge
Boman Index
Hydrophobicity
Aliphatic Index
Half Life
Extinction Coefficient cystines
Absorbance 280nm
Polar residues
Literature Information
Literature 1
Title alpha-Defensin inhibits influenza virus replication by cell-mediated mechanism(s)
Pubmed ID 17703413
Reference The Journal of infectious diseases, 196(6), 835–843
Author Mirella Salvatore 1, Adolfo Garcia-Sastre, Piotr Ruchala, Robert I Lehrer, Theresa Chang, Mary E Klotman
DOI 10.1086/521027
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.