General Information


DRAVP ID  DRAVPe02092

Peptide Name   Alpha-basrubrin

Sequence  GADFQECMKEHSQKQHQHQG

Sequence Length  20

UniProt ID  P83186 

Taxon ID  3589 

Source  isolated from seeds of the Ceylon spinach Basella rubra

Validation   Experimentally Validated



Origin Information


Gene Name/ID  Not Available

GenBank  Not Available

Amino Acid position  1to20

Domain Accession ID  Not Available

Nucleotide sequence ID  Not Available

Molecular Type  Not Available

Chromosomal Position  Not Available



Activity Information


Target Organism  HIV

Assay  ELISA

Activity 

  • [Ref:11688973]HIV-1: Alpha-Basrubrin inhibited reverse transcriptase activity (79.4 ± 7.8% at 400 µM, 10.6 ± 0.9% at 40 µM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity  No cytotoxicity information found in the reference(s) presented

Binding Target  Not given

Mechanism  Inhibits HIV-1 reverse transcriptase and cell-free translation



Structure Information


PDB ID  None

Predicted Structure Download  No predicted structure available

Linear/Cyclic 

N-terminal Modification 

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  C96H145N33O33S2

Absent amino acids  RNILTWYVOU

Common amino acids  Q

Mass  2353.53

Pl  6.27

Basic residues  2

Acidic residues  3

Hydrophobic residues  0

Net charge  -1

Boman Index  3.41

Hydrophobicity  -1.9

Aliphatic Index  5

Half Life 

  •     Mammalian:30 hours
  •     Yeast:>20 hours
  •     E.coli:>10 hours

Extinction Coefficient cystines  0

Absorbance 280nm  0

Polar residues  0



Literature Information


Literature 1

Title   Novel antifungal peptides from Ceylon spinach seeds

Pubmed ID   11688973

Reference   Biochemical and biophysical research communications, 288(4), 765–770.

Author   Wang, H., & Ng, T. B. (2001)

DOI   10.1006/bbrc.2001.5822