To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.
General Information
DRAVP ID DRAVPe02094
Peptide Name Melittin of bee venom
Sequence GIGAVLKYLTTGLPALISWIKRKROQ
Sequence Length 26
UniProt ID None
Taxon ID None
Source Bee Venom
Validation Experimentally Validated
Origin Information
Gene Name/ID Not Available
GenBank Not Available
Amino Acid position Not Available
Domain Accession ID Not Available
Nucleotide sequence ID Not Available
Molecular Type Not Available
Chromosomal Position Not Available
Activity Information
Target Organism SARS-CoV-2
Assay MTT assay/ RT-qPCR Assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity
Binding Target Membrane
Mechanism Melittin disrupts viral membranes, activates Toll-like receptors to reduce inflammatory cytokines, suppresses metabolic regulators like transketolase, and activates host RNA-binding proteins,
Structure Information
PDB ID None
Predicted Structure Download No predicted structure available
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C142H239N39O33
Absent amino acids NDCHMFU
Common amino acids ARGILKT
Mass 3020.7
Pl 11.17
Basic residues 5
Acidic residues 0
Hydrophobic residues 16
Net charge 5
Boman Index 2.21
Hydrophobicity 0.196
Aliphatic Index 123.85
Half Life
Extinction Coefficient cystines 6990
Absorbance 280nm 2.314
Polar residues 10
Literature Information
Literature 1
Title Gramicidin S and melittin: potential anti-viral therapeutic peptides to treat SARS-CoV-2 infection
Pubmed ID 35236909
Reference Scientific reports, 12(1), 3446
Author Enayathullah, M. G., Parekh, Y., Banu, S., Ram, S., Nagaraj, R., Kumar, B. K., & Idris, M. M
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.