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General Information
DRAVP ID DRAVPe02096
Peptide Name Mastoparan-L
Sequence INLKALAALAKKIL
Sequence Length 14
UniProt ID P01514
Taxon ID 7452
Source Venom, Vespula lewisii
Validation Experimentally Validated
Origin Information
Gene Name/ID Not Available
GenBank Not Available
Amino Acid position 1to14
Domain Accession ID Not Available
Nucleotide sequence ID Not Available
Molecular Type Not Available
Chromosomal Position Not Available
Activity Information
Target Organism HSV-1
Assay Plaque Assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity
Binding Target Membrane
Mechanism Mastoparan can be classified as entry inhibitors, for which characteristics such as cationicity and hydrophobicity play a significant role, primarily against enveloped viruses. Nevertheless, further assays with other enveloped and non-enveloped viruses are needed to address this matter.mastoparan, it is inferred that this peptide may also affect lipid vesicles mimicking the viral envelope
Structure Information
Predicted Structure Download No predicted structure available
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Amination
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C70H130N18O16
Absent amino acids RDCQEGHMFPSTWYVOU
Common amino acids AILK
Mass 1479.91
Pl 10.3
Basic residues 3
Acidic residues 0
Hydrophobic residues 10
Net charge 3
Boman Index -0.96
Hydrophobicity 1.157
Aliphatic Index 195.71
Half Life
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 4
Literature Information
Literature 1
Title Antiviral Activities of Mastoparan-L-Derived Peptides against Human Alphaherpesvirus 1
Pubmed ID 38932240
Reference Viruses. 2024 Jun 12;16(6)
Author Vilas Boas LCP, Buccini DF, Berlanda RLA, Santos BPO, Maximiano MR, Lião LM, Gonçalves S, Santos NC, Franco OL.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.