DRAVP ID  DRAVPe02097

Peptide Name   [I5, R8]Mastoparan

Sequence  INLKILARLAKKIL

Sequence Length  14

UniProt ID  P01514 

Taxon ID  7452 

Source  Venom, Vespula lewisii

Validation   Experimentally Validated

Gene Name/ID  Not Available

GenBank  Not Available

Amino Acid position  Not Available

Domain Accession ID  Not Available

Nucleotide sequence ID  Not Available

Molecular Type  Not Available

Chromosomal Position  Not Available

Target Organism  HSV-1

Assay  Plaque Assay

Activity 

• [Ref:38932240]Human alphaherpesvirus 1 (HSV-1): Inhibited entry (EC50 = 6.22 µM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

• [Ref:38932240]CC50 > 50 µg.mL−1. Mastoparan showed no cytotoxicity even at higher concentrations (LC50 > 200 µM).However, in THP-1-derived macrophages, LC50 ranged between 24.5~12.9 µM.

Binding Target  Membrane

Mechanism  Mastoparan can be classified as entry inhibitors, for which characteristics such as cationicity and hydrophobicity play a significant role, primarily against enveloped viruses. Nevertheless, further assays with other enveloped and non-enveloped viruses are needed to address this matter.mastoparan, it is inferred that this peptide may also affect lipid vesicles mimicking the viral envelope

PDB ID  6DUL  1D7N 

Predicted Structure Download  No predicted structure available

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Amination

Other Modification  None

Stereochemistry  L

Literature 1

Title   Antiviral Activities of Mastoparan-L-Derived Peptides against Human Alphaherpesvirus 1

Pubmed ID   38932240

Reference   Viruses. 2024 Jun 12;16(6)

Author   Vilas Boas LCP, Buccini DF, Berlanda RLA, Santos BPO, Maximiano MR, Lião LM, Gonçalves S, Santos NC, Franco OL.

DOI    10.3390/v16060948