To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.
General Information
DRAVP ID DRAVPe02098
Peptide Name Alloferon 1
Sequence HGVSGHGQHGVHG
Sequence Length 13
UniProt ID P83412
Taxon ID 7373
Source Calliphora vicina (Blue blowfly) (Calliphora erythrocephala)
Other Link DRAVPa1831
Validation Experimentally Validated
Origin Information
Gene Name/ID Not Available
GenBank Not Available
Amino Acid position 1to13
Domain Accession ID Not Available
Nucleotide sequence ID Not Available
Molecular Type Not Available
Chromosomal Position Not Available
Activity Information
Target Organism HHV-1,IAV
Assay Antiviral activity assay.
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity No cytotoxicity information found in the reference(s) presented
Binding Target Membrane
Mechanism Alloferon can (i) stimulate natural cytotoxicity of human peripheral blood lymphocytes, (ii) induces IFN synthesis in mouse and human models, and (iii) enhances antiviral and antitumor resistance in mice.
Structure Information
PDB ID None
Predicted Structure Download No predicted structure available
Linear/Cyclic Linear
N-terminal Modification Carboxylation
C-terminal Modification Amidation
Other Modification The three imidazoles of H1, H6, and H9 participate in the coordination of Zn(II)
Stereochemistry L
Physicochemical Information
Formula C52H76N22O16
Absent amino acids ARNDCEILMKFPTWYOU
Common amino acids GH
Mass 1265.15
Pl 7.1
Basic residues 4
Acidic residues 0
Hydrophobic residues 2
Net charge 4
Boman Index -14.8
Hydrophobicity 0.9
Aliphatic Index 209.29
Half Life
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 4
Literature Information
Literature 1
Title Further studies on the antiviral activity of alloferon and its analogues
Pubmed ID 21766388
Reference Journal of peptide science : an official publication of the European Peptide Society, 17(11), 715–719
Author Kuczer, M., Midak-Siewirska, A., Zahorska, R., Luczak, M., & Konopińska, D. (2011)
DOI 10.1002/psc.1388
Literature 2
Title Antiviral and antitumor peptides from insects
Pubmed ID 12235362
Reference Proceedings of the National Academy of Sciences of the United States of America, 99(20), 12628–12632.
Author Chernysh, S., Kim, S. I., Bekker, G., Pleskach, V. A., Filatova, N. A., Anikin, V. B., Platonov, V. G., & Bulet, P. (2002).
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.