To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.
General Information
DRAVP ID DRAVPe02099
Peptide Name Alloferon 2
Sequence GVSGHGQHGVHG
Sequence Length 12
UniProt ID P83412
Taxon ID 7373
Source Calliphora vicina (Blue blowfly) (Calliphora erythrocephala)
Other Link DRAVPa1832
Validation Experimentally Validated
Origin Information
Gene Name/ID Not Available
GenBank Not Available
Amino Acid position 2to13
Domain Accession ID Not Available
Nucleotide sequence ID Not Available
Molecular Type Not Available
Chromosomal Position Not Available
Activity Information
Target Organism IAV,IBV
Assay Antiviral activity assay.
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity No cytotoxicity information found in the reference(s) presented
Binding Target Membrane
Mechanism Alloferon can (i) stimulate natural cytotoxicity of human peripheral blood lymphocytes, (ii) induces IFN synthesis in mouse and human models, and (iii) enhances antiviral and antitumor resistance in mice.
Structure Information
PDB ID None
Predicted Structure Download No predicted structure available
Linear/Cyclic Linear
N-terminal Modification Carboxylation
C-terminal Modification amidation
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C46H69N19O15
Absent amino acids ARNDCEILMKFPTWYOU
Common amino acids GH
Mass 1128.63
Pl 7.02
Basic residues 3
Acidic residues 0
Hydrophobic residues 2
Net charge 3
Boman Index -10.14
Hydrophobicity -0.823
Aliphatic Index 44.62
Half Life
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 6
Literature Information
Literature 1
Title Antiviral and antitumor peptides from insects
Pubmed ID 12235362
Reference Proceedings of the National Academy of Sciences of the United States of America, 99(20), 12628–12632.
Author Chernysh, S., Kim, S. I., Bekker, G., Pleskach, V. A., Filatova, N. A., Anikin, V. B., Platonov, V. G., & Bulet, P. (2002).
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.