General Information


DRAVP ID  DRAVPe02101

Peptide Name   GLRC-8

Sequence  GLRCLRLRGRLRLGRCLLR

Sequence Length  19

UniProt ID  None  

Taxon ID  None 

Source  De novo designed

Validation   De Novo



Origin Information


Gene Name/ID  Not Available

GenBank  Not Available

Amino Acid position  Not Available

Domain Accession ID  Not Available

Nucleotide sequence ID  Not Available

Molecular Type  Not Available

Chromosomal Position  Not Found



Activity Information


Target Organism  HIV-1IIIB

Assay  Anti-HIV assays

Activity 

  • [Ref:Not Available]HIV: EC50>100 µg/ml in CEM-SS cells

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

  • TC50:31 µg/ml in CEM-SS cells

Binding Target  Not Found

Mechanism  Not Available



Structure Information


PDB ID  None

Predicted Structure Download  No predicted structure available

Linear/Cyclic  Linear

N-terminal Modification  Not included yet

C-terminal Modification  Not included yet

Other Modification  C4-C16 disulfide linkage

Stereochemistry  L



Physicochemical Information


Formula  C96H182N40O20S2

Absent amino acids  ANDQEHIKMFPSTWYVOU

Common amino acids  RL

Mass  2280.88

Pl  12.13

Basic residues  6

Acidic residues  0

Hydrophobic residues  12

Net charge  6

Boman Index  1.12

Hydrophobicity  -0.058

Aliphatic Index  143.68

Half Life 

  •     Mammalian:30 hours
  •     Yeast:>20 hours
  •     E.coli:>10 hours

Extinction Coefficient cystines  0

Absorbance 280nm  0

Polar residues  16



Literature Information


Literature 1

Title   De Novo Design of Antiviral and Antibacterial Peptides with Varying Loop Structures

Pubmed ID   Not Avaialbe

Reference   Reginald et al. J AIDS Clinic Res 2011, S3

Author   Wang G, Watson KM, Mishra B, Lushnikova T, Buckheit RW Jr. 2012

DOI   10.4172/2155-6113.S2-004