To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.
General Information
DRAVP ID DRAVPe02113
Peptide Name Esculentin-1GN
Sequence GLFSKKGGKGGKSWIKGVFKGIKGIGKEVGGDVIRTGIEIAACKIKGEC
Sequence Length 46
UniProt ID None
Taxon ID A0A3G6VAR4
Source The crawfish frog, Rana areolata, North America
Validation Experimentally validated
Origin Information
Gene Name/ID 110109
GenBank Not Available
Amino Acid position 39-87
Domain Accession ID Not Available
Nucleotide sequence ID Not Available
Molecular Type Not Available
Chromosomal Position mRNA
Activity Information
Target Organism IAV(H1N1)
Assay Inhibition Assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity No cytotoxicity information found in the reference(s) presented
Binding Target Cell Membrane
Mechanism ESC-1GN disrupted membrane fusion activity of IAVs by interaction with HA2 subunit
Structure Information
PDB ID None
Predicted Structure Download No predicted structure available
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Free
Other Modification E105, N50 and the residues around them on HA2 subunit could form hydrogen bonds with amino acid on ESC-1GN
Stereochemistry L
Physicochemical Information
Formula C225H379N63O61S2
Absent amino acids NQHMPYOU
Common amino acids G
Mass 5006.99
Pl 9.87
Basic residues 11
Acidic residues 4
Hydrophobic residues 24
Net charge 7
Boman Index 0.62
Hydrophobicity -0.078
Aliphatic Index 85.51
Half Life
Extinction Coefficient cystines 5500
Absorbance 280nm 1.098
Polar residues 32
Literature Information
Literature 1
Title Antiviral activity and mechanism of ESC-1GN from skin secretion of Hylarana guentheri against influenza A virus
Pubmed ID 33624755
Reference Journal of biochemistry, 169(6), 757–765.
Author Yang, J., Zhang, B., Huang, Y., Liu, T., Zeng, B., Chai, J., Wu, J., & Xu, X. (2021).
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.