To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.
General Information
DRAVP ID DRAVPe02114
Peptide Name Esculentin-2P
Sequence GFSSIFRGVAKFASKGLGKDLARLGVNLVACKISKQC
Sequence Length 37
UniProt ID None
Taxon ID None
Source North American frog, Rana pipiens
Validation Experimentally validated
Origin Information
Gene Name/ID Not Available
GenBank Not Available
Amino Acid position Not Available
Domain Accession ID Not Available
Nucleotide sequence ID Not Available
Molecular Type Not Available
Chromosomal Position Not Found
Activity Information
Target Organism HIV-1
Assay HIV infection and cell viability assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity No cytotoxicity information found in the reference(s) presented
Binding Target Envelope/outer leaflet of the membrane
Mechanism Highly effective in inhibiting HIV infection by disrupting the viral membrane and preventing the entry of the virus into target cells.
Structure Information
PDB ID None
Predicted Structure Download No predicted structure available
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C173H290N50O46S2
Absent amino acids HPTWYOU
Common amino acids GK
Mass 3870.63
Pl 10.21
Basic residues 7
Acidic residues 1
Hydrophobic residues 18
Net charge 6
Boman Index 0.73
Hydrophobicity 0.357
Aliphatic Index 97.57
Half Life
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 24
Literature Information
Literature 1
Title Antimicrobial peptides from amphibian skin potently inhibit human immunodeficiency virus infection and transfer of virus from dendritic cells to T cells
Pubmed ID 16140737
Reference Journal of virology, 79(18), 11598–11606.
Author VanCompernolle, S. E., Taylor, R. J., Oswald-Richter, K., Jiang, J., Youree, B. E., Bowie, J. H., Tyler, M. J., Conlon, J. M., Wade, D., Aiken, C., Dermody, T. S., KewalRamani, V. N., Rollins-Smith, L. A., & Unutmaz, D. (2005)
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.