General Information


DRAVP ID  DRAVPe02115

Peptide Name   Frenatin-2

Sequence  GLLGTLGNLLNGLGL

Sequence Length  15

UniProt ID  P82022 

Taxon ID  61195 

Source  White-lipped treefrog Litoria infrafrenata, Australia

Validation   Experimentally validated



Origin Information


Gene Name/ID  Not Available

GenBank  Not Available

Amino Acid position  1to 15

Domain Accession ID  Not Available

Nucleotide sequence ID  Not Available

Molecular Type  Not Available

Chromosomal Position  Not Found



Activity Information


Target Organism  YFV

Assay  antiviral colorimetric assay

Activity  Not Available

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

  • [Ref:27049440]CMs were not cytotoxic to the CHO-K1 cell line

Binding Target  Not Found

Mechanism  Not Available



Structure Information


PDB ID  None

Predicted Structure Download  No predicted structure available

Linear/Cyclic  Cyclic

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  C64H113N17O19

Absent amino acids  ARDCQEHIKMFPSWYVOU

Common amino acids  L

Mass  1424.7

Pl  5.52

Basic residues  0

Acidic residues  0

Hydrophobic residues  10

Net charge  0

Boman Index  -1.55

Hydrophobicity  1.127

Aliphatic Index  182

Half Life 

  •     Mammalian:30 hours
  •     Yeast:>20 hours
  •     E.coli:>10 hours

Extinction Coefficient cystines  0

Absorbance 280nm  0

Polar residues  12



Literature Information


Literature 1

Title   Frog skin cultures secrete anti-yellow fever compounds

Pubmed ID   27049440

Reference   The Journal of antibiotics, 69(11), 783–790.

Author   Muñoz-Camargo, C., Méndez, M. C., Salazar, V., Moscoso, J., Narváez, D., Torres, M. M., Florez, F. K., Groot, H., & Mitrani, E. (2016).

DOI   10.1038/ja.2016.16