General Information


DRAVP ID  DRAVPe02116

Peptide Name   Frenatin 2.3S

Sequence  GLVGTLLGHIGKAILGG

Sequence Length  17

UniProt ID  L0L3V3 

Taxon ID  279984 

Source  The Orinoco lime treefrog, Sphaenorhynchus lacteus, South America

Validation   Experimentally validated



Origin Information


Gene Name/ID  Not Available

GenBank  Not Available

Amino Acid position  55-71

Domain Accession ID  AGB51284.1  

Nucleotide sequence ID  Not Available

Molecular Type  Not Available

Chromosomal Position  Not Found



Activity Information


Target Organism  YFV

Assay  antiviral colorimetric assay

Activity 

  • [Ref:27049440]YFV: 35% protective effect in Vero E6 cells at 20 µg/ml

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

  • [Ref:27049440]VeroE6: No cytotoxicity at 100 µg/ml

Binding Target  Not Found

Mechanism  Not Available



Structure Information


PDB ID  None

Predicted Structure Download  No predicted structure available

Linear/Cyclic  Cyclic

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  C72H126N20O19

Absent amino acids  RNDCQEMFPSTWYOU

Common amino acids  G

Mass  1575.91

Pl  8.76

Basic residues  1

Acidic residues  0

Hydrophobic residues  12

Net charge  1

Boman Index  -1.66

Hydrophobicity  1.176

Aliphatic Index  160.59

Half Life 

  •     Mammalian:30 hours
  •     Yeast:>20 hours
  •     E.coli:>10 hours

Extinction Coefficient cystines  0

Absorbance 280nm  0

Polar residues  14



Literature Information


Literature 1

Title   Frog skin cultures secrete anti-yellow fever compounds

Pubmed ID   27049440

Reference   The Journal of antibiotics, 69(11), 783–790.

Author   Muñoz-Camargo, C., Méndez, M. C., Salazar, V., Moscoso, J., Narváez, D., Torres, M. M., Florez, F. K., Groot, H., & Mitrani, E. (2016).

DOI   10.1038/ja.2016.16