DRAVP ID  DRAVPe02119

Peptide Name   Hc-CATH

Sequence  KFFKRLLKSVRRAVKKFRKKPRLIGLSTLL

Sequence Length  30

UniProt ID  A0A0G3DRW6 

Taxon ID  8686 

Source  Venom gland, spleen, and lung, annulated sea snake, Hydrophis cyanocinctus

Validation   Experimentally validated

Gene Name/ID  Not Available

GenBank  Not Available

Amino Acid position  158-171

Domain Accession ID  Not Available

Nucleotide sequence ID  Not Available

Molecular Type  Not Available

Chromosomal Position  Not Found

Target Organism  ZIKV

Assay  Inhibition Assay

Activity 

• [Ref:36089062]ZIKV: At 5 µM, reduced 70.3% CPE, 52.7% RNA, 67.4% NS3, 71.6% particles

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

• [Ref:36089062]MammalianCells: No cytotoxicity at 1.25, 2.5, and 5 µM

Binding Target  Cell Membrane

Mechanism  Hc-CATH can bind to ZIKV, disrupt viral membrane, induce the leakage of viral genomic RNA, and then inactivate ZIKV virions

PDB ID  None

Predicted Structure Download  No predicted structure available

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L

Literature 1

Title   A cathelicidin antimicrobial peptide from Hydrophis cyanocinctus inhibits Zika virus infection by downregulating expression of a viral entry factor

Pubmed ID   36089062

Reference   The Journal of biological chemistry, 298(10), 102471.

Author   Wang, J., Jiang, B., Wang, K., Dai, J., Dong, C., Wang, Y., Zhang, P., Li, M., Xu, W., & Wei, L. (2022).

DOI   10.1016/j.jbc.2022.102471