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General Information
DRAVP ID DRAVPe02120
Peptide Name HD-5(1–9)
Sequence ATCYCRTGR
Sequence Length 9
UniProt ID Q01523
Taxon ID 9606
Source H. sapiens
Validation Experimentally validated
Origin Information
Gene Name/ID DEFA5(1670)
GenBank AAA35754.1
Amino Acid position 63-71
Domain Accession ID M97925.1
Nucleotide sequence ID CM000670.2
Molecular Type Genomic DNA
Chromosomal Position chr8:7055304-7056739:-
Activity Information
Target Organism HCMV
Assay Inhibition Assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity
Binding Target Cell Membrane
Mechanism HD5(1–9) inhibited HCMV cellular attachment and thereby entry and was active against primary as well as a multiresistant HCMV isolate
Structure Information
PDB ID 1ZMP
Predicted Structure Download No predicted structure available
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C40H67N15O13S2
Absent amino acids NDQEHILKMFPSTWVOU
Common amino acids RCT
Mass 1030.18
Pl 8.96
Basic residues 2
Acidic residues 0
Hydrophobic residues 8
Net charge 2
Boman Index 3.31
Hydrophobicity -0.589
Aliphatic Index 11.11
Half Life
Extinction Coefficient cystines 1490
Absorbance 280nm 1.446
Polar residues 9
Literature Information
Literature 1
Title The human α-defensin-derived peptide HD5(1-9) inhibits cellular attachment and entry of human cytomegalovirus
Pubmed ID 32209394
Reference Antiviral research, 177, 104779.
Author Böffert, R., Businger, R., Preiß, H., Ehmann, D., Truffault, V., Simon, C., Ruetalo, N., Hamprecht, K., Müller, P., Wehkamp, J., & Schindler, M. (2020).
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.