To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.
General Information
DRAVP ID DRAVPe02121
Peptide Name Human histatin 5
Sequence DSHAKRHHGYKRKFHEKHHSHRGY
Sequence Length 24
UniProt ID P15516
Taxon ID 9606
Source Salivary glands, H. sapiens
Validation Experimentally validated
Origin Information
Gene Name/ID HTN3
GenBank AAA58646.1
Amino Acid position 20-43
Domain Accession ID M26665.1
Nucleotide sequence ID CM000666.2
Molecular Type mRNA
Chromosomal Position Chromosome 4: 70,028,455-70,036,538
Activity Information
Target Organism HIV
Assay Peptide depletion assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity No cytotoxicity information found in the reference(s) presented
Binding Target Membrane
Mechanism Dh-5 inhibited HIV-1 replication
Structure Information
PDB ID None
Predicted Structure Download No predicted structure available
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C133H195N51O33
Absent amino acids NCQILMPTWVOU
Common amino acids H
Mass 3036.33
Pl 10.28
Basic residues 7
Acidic residues 2
Hydrophobic residues 18
Net charge 5
Boman Index 4.81
Hydrophobicity -2.454
Aliphatic Index 4.17
Half Life
Extinction Coefficient cystines 2980
Absorbance 280nm 0.981
Polar residues 22
Literature Information
Literature 1
Title Histatin 5-derived peptide with improved fungicidal properties enhances human immunodeficiency virus type 1 replication by promoting viral entry
Pubmed ID 16940535
Reference Journal of virology, 80(18), 9236–9243
Author Groot, F., Sanders, R. W., ter Brake, O., Nazmi, K., Veerman, E. C., Bolscher, J. G., & Berkhout, B. (2006).
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.