To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.
General Information
DRAVP ID DRAVPe02122
Peptide Name Hepcidin 1–5
Sequence GIKCRFCCGCCTPGICGVCCRF
Sequence Length 22
UniProt ID None
Taxon ID 106582
Source tilapia, Oreochromis mossambicus
Validation Experimentally validated
Origin Information
Gene Name/ID Not Available
GenBank Not Available
Amino Acid position Not Available
Domain Accession ID Not Available
Nucleotide sequence ID Not Available
Molecular Type Not Available
Chromosomal Position Not Found
Activity Information
Target Organism NNV
Assay Not Available
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity No cytotoxicity information found in the reference(s) presented
Binding Target Membrane
Mechanism The mechanism of action (MOA) of hepcidin 1-5 against the nervous necrosis virus (NNV) involves a combination of direct antiviral and immunomodulatory effects. Hepcidin 1-5 functions as a lytic peptide, disrupting the viral structure through direct interaction, as demonstrated in vitro. Additionally, treatment with hepcidin 1-5 was shown to downregulate NNV gene expression, as verified by RT-PCR, indicating its ability to inhibit viral replication or transcription. The peptide also modulates the host immune response by reducing interferon gene expression, which may help control excessive inflammation while supporting viral clearance. Importantly, hepcidin 1-5 proved effective in pretreatment, co-treatment, and post-treatment scenarios, demonstrating its versatility in preventing infection, combating active viral presence, and rescuing infected organisms
Structure Information
PDB ID None
Predicted Structure Download No predicted structure available
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C94H153N29O24S8
Absent amino acids ANDQEHLMSWYOU
Common amino acids C
Mass 2329.91
Pl 8.54
Basic residues 3
Acidic residues 0
Hydrophobic residues 18
Net charge 3
Boman Index 0.81
Hydrophobicity 1
Aliphatic Index 48.64
Half Life
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 24
Literature Information
Literature 1
Title Antiviral activity by fish antimicrobial peptides of epinecidin-1 and hepcidin 1–5 against nervous necrosis virus in medaka
Pubmed ID 20214942
Reference Peptides, 31(6), 1026–1033.
Author Wang, Y. D., Kung, C. W., & Chen, J. Y. (2010).
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.