DRAVP ID  DRAVPe02133

Peptide Name   Malformin C

Sequence  XCXCVXLL

Sequence Length  6

UniProt ID  None  

Taxon ID  None 

Source  marine-derived fungus Aspergillus niger SCSIO Jcsw6F30

Validation   Experimentally Validated

Gene Name/ID  Not Available

GenBank  Not Available

Amino Acid position  Not Available

Domain Accession ID  Not Available

Nucleotide sequence ID  Not Available

Molecular Type  Not Available

Chromosomal Position  Not Available

Target Organism  HIV-1

Assay  HIV integrase inhibition assay

Activity 

• [Ref:26711143]HIV-1:IC50=1.4±0.06μM

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

• [Ref:26711143]No cytotoxicity

Binding Target  Not found

Mechanism  Not Available

PDB ID  None

Predicted Structure Download  No predicted structure available

Linear/Cyclic  Cyclic

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  X1 at position 1: D-Cys → Cysteine in D-configuration (mirror image of natural L-Cys),X2 at position 2: D-Cys → D-isomer of Cysteine,X at position 4: D-Leu → Leucine in D-form,Cyclic structure: The peptide is cyclized, forming a closed ring via peptide bonds, often enhancing stability and bioactivity.

Stereochemistry  L

Literature 1

Title   Aspernigrins with anti-HIV-1 activities from the marine-derived fungus Aspergillus nigerSCSIO Jcsw6F30

Pubmed ID   26711143

Reference   Bioorganic & medicinal chemistry letters, 26(2), 361–365.

Author   Zhou, X., Fang, W., Tan, S., Lin, X., Xun, T., Yang, B., Liu, S., & Liu, Y. (2016)

DOI   10.1016/j.bmcl.2015.12.005