To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.
General Information
DRAVP ID DRAVPe02137
Peptide Name Aspergillipeptide D
Sequence VXYXYXYP
Sequence Length 5
UniProt ID None
Taxon ID None
Source Endophytic fungus Aspergillus sp. SCSIO 41501
Validation Experimentally Validated
Origin Information
Gene Name/ID Not Available
GenBank Not Available
Amino Acid position Not Available
Domain Accession ID Not Available
Nucleotide sequence ID Not Available
Molecular Type Not Available
Chromosomal Position Not Available
Activity Information
Target Organism HSV-1
Assay plaque reduction assay.
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity
Binding Target Glycoprotein.
Mechanism Aspergillipeptide D did not affect HSV-1 early infection events, including viral inactivation, attachment and penetration. Interestingly, Aspergillipeptide D dramatically reduced both the gene and protein levels of viral late protein gB, and suppressed its location in the endoplasmic reticulum and Golgi apparatus.n contrast, overexpression of gB restored viral production. Finally, proteomic analysis revealed that the numbers of cellular proteins that interacted with gB protein was largely decreased by Aspergillipeptide D. These results suggested that Aspergillipeptide D inhibited gB function to affect HSV-1 intercellular spread.
Structure Information
PDB ID None
Predicted Structure Download No predicted structure available
Linear/Cyclic Cyclic
N-terminal Modification Free
C-terminal Modification Free
Other Modification X at position 2: N-methyltyrosine (N-Me-Tyr) → Y (Tyrosine with a methyl group on the nitrogen),X at position 3: O-methyltyrosine (O-Me-Tyr) → Y (Tyrosine with a methyl group on the hydroxyl group),X at position 4: O-methyltyrosine (O-Me-Tyr) → Y (Tyrosine with a methyl group on the hydroxyl group)
Stereochemistry L
Physicochemical Information
Formula C40H49N5O8
Absent amino acids ARNDCQWMFSTWOU
Common amino acids Y
Mass 727.859 g/mol
Pl 5.49
Basic residues 0
Acidic residues 0
Hydrophobic residues 5
Net charge 0
Boman Index 0.84
Hydrophobicity -0.26
Aliphatic Index 58
Half Life
Extinction Coefficient cystines 1470
Absorbance 280nm 6.351
Polar residues 5
Literature Information
Literature 1
Title Antiviral peptides from marine gorgonian-derived fungus Aspergillus sp. SCSIO 41501
Pubmed ID 32192525
Reference Virology journal, 17(1), 41.
Author Wang, Z., Jia, J., Wang, L., Li, F., Wang, Y., Jiang, Y., Song, X., Qin, S., Zheng, K., Ye, J., Ren, Z., Wang, Y., & Qi, S. (2020).
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.