General Information


DRAVP ID  DRAVPe02141

Peptide Name   Acremonpeptide A

Sequence  FLSX₃

Sequence Length  3

UniProt ID  None  

Taxon ID  None 

Source  Fungus Acremonium persicinum SCSIO 115

Validation   Experimentally Validated



Origin Information


Gene Name/ID  Not Available

GenBank  Not Available

Amino Acid position  Not Available

Domain Accession ID  Not Available

Nucleotide sequence ID  Not Available

Molecular Type  Not Available

Chromosomal Position  Not Available



Activity Information


Target Organism  HSV-1,HSV-2

Assay  Vitro Bioassay

Activity 

  • [Ref:31503476]HSV-1:IC50=16μM,HSV-1:EC50=8.7μM

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity  No cytotoxicity information found in the reference(s) presented

Binding Target  Cell membrane

Mechanism  Viral Replication



Structure Information


PDB ID  None

Predicted Structure Download  No predicted structure available

Linear/Cyclic  Cyclic

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  X = Modified ornithine (specifically N5-acetyl-N5-hydroxy-Orn, repeated three times)

Stereochemistry  L



Physicochemical Information


Formula  C39H61N9O13

Absent amino acids  ARNDCQEMPWVOU

Common amino acids  FLS

Mass  365.19

Pl  5.9

Basic residues  0

Acidic residues  0

Hydrophobic residues  2

Net charge  0

Boman Index  0.46

Hydrophobicity  1.93

Aliphatic Index  81.6

Half Life 

  •     Mammalian:1.1 hours
  •     Yeast:20 mins
  •     E.coli:10 mins

Extinction Coefficient cystines  0

Absorbance 280nm  0

Polar residues  1



Literature Information


Literature 1

Title   Natural Hydroxamate-Containing Siderophore Acremonpeptides A-D and an Aluminum Complex of Acremonpeptide D from the Marine-Derived Acremonium persicinum SCSIO 115

Pubmed ID   31503476

Reference   Journal of natural products, 82(9), 2594–2600.

Author   Luo, M., Zang, R., Wang, X., Chen, Z., Song, X., Ju, J., & Huang, H. (2019).

DOI   10.1021/acs.jnatprod.9b00545