General Information


DRAVP ID  DRAVPe02142

Peptide Name   Al(III)-acremonpeptide D

Sequence  FLWXOX

Sequence Length  4

UniProt ID  None  

Taxon ID  None 

Source  Fungus Acremonium persicinum SCSIO 115

Validation   Experimentally Validated



Origin Information


Gene Name/ID  Not Available

GenBank  Not Available

Amino Acid position  Not Available

Domain Accession ID  Not Available

Nucleotide sequence ID  Not Available

Molecular Type  Not Available

Chromosomal Position  Not Available



Activity Information


Target Organism  HSV-1

Assay  Anti-HSV-Assay

Activity 

  • [Ref:31503476]HSV-1:IC50=14μM

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity  No cytotoxicity information found in the reference(s) presented

Binding Target  Cell membrane

Mechanism  Viral replication



Structure Information


PDB ID  None

Predicted Structure Download  No predicted structure available

Linear/Cyclic  Cyclic

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  X = AcN(OH)Orn

Stereochemistry  L



Physicochemical Information


Formula  C47H63AlN10O12

Absent amino acids  ARNDCQEMPSVOU

Common amino acids  FLW

Mass  578.3

Pl  9.9

Basic residues  1

Acidic residues  0

Hydrophobic residues  2

Net charge  1

Boman Index  1.95

Hydrophobicity  1.18

Aliphatic Index  87.5

Half Life 

  •     Mammalian:30 hours
  •     Yeast:>20 hours
  •     E.coli:>10 hours

Extinction Coefficient cystines  0

Absorbance 280nm  0

Polar residues  2



Literature Information


Literature 1

Title   Natural Hydroxamate-Containing Siderophore Acremonpeptides A-D and an Aluminum Complex of Acremonpeptide D from the Marine-Derived Acremonium persicinum SCSIO 115

Pubmed ID   31503476

Reference   Journal of natural products, 82(9), 2594–2600.

Author   Luo, M., Zang, R., Wang, X., Chen, Z., Song, X., Ju, J., & Huang, H. (2019).

DOI   10.1021/acs.jnatprod.9b00545