General Information


DRAVP ID  DRAVPe02143

Peptide Name   Myticin C

Sequence  QSVACRSYYCSKFCGSAGCSLYGCYLLHPGKICYCLHCSR

Sequence Length  40

UniProt ID  A7DWR7 

Taxon ID  29158 

Source  Mollusk Mytilus galloprovincialis

Validation   Experimentally Validated



Origin Information


Gene Name/ID  mync_MYTGA

GenBank  Not Available

Amino Acid position  21-60

Domain Accession ID  Not Available

Nucleotide sequence ID  Not Available

Molecular Type  Not Available

Chromosomal Position  Not Available



Activity Information


Target Organism  HSV-1

Assay  Anti-HSV-Assay

Activity 

  • [Ref:27307570]HSV-1:IC50=7.69–8.21μM,HSV-1:IC50=8.32–10.5μM

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity  No cytotoxicity information found in the reference(s) presented

Binding Target  Not found

Mechanism  The intracellular phase of viral replication



Structure Information


PDB ID  None

Predicted Structure Download  No predicted structure available

Linear/Cyclic  Cyclic

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  C191H289N53O53S8

Absent amino acids  NDEMTWOU

Common amino acids  C

Mass  4432.2

Pl  8.71

Basic residues  4

Acidic residues  0

Hydrophobic residues  18

Net charge  4

Boman Index  0.9185

Hydrophobicity  0.227

Aliphatic Index  61

Half Life 

  •     Mammalian:0.8 hours
  •     Yeast:10 min
  •     E.coli:10 hours

Extinction Coefficient cystines  7450

Absorbance 280nm  1.681

Polar residues  12



Literature Information


Literature 1

Title   Antiviral Activity of Myticin C Peptide from Mussel: an Ancient Defense against Herpesviruses

Pubmed ID   27307570

Reference   Journal of virology, 90(17), 7692–7702.

Author   Novoa, B., Romero, A., Álvarez, Á. L., Moreira, R., Pereiro, P., Costa, M. M., Dios, S., Estepa, A., Parra, F., & Figueras, A. (2016).

DOI   10.1128/JVI.00591-16