General Information


DRAVP ID  DRAVPe02145

Peptide Name   Cyclo(l-Tyr-l-Pro) diketopiperazine

Sequence  YP

Sequence Length  2

UniProt ID  None  

Taxon ID  None 

Source  Endophytic fungus Aspergillus versicolor

Validation   Experimentally Validated



Origin Information


Gene Name/ID  Not Available

GenBank  Not Available

Amino Acid position  Not Available

Domain Accession ID  Not Available

Nucleotide sequence ID  Not Available

Molecular Type  Not Available

Chromosomal Position  Not Available



Activity Information


Target Organism  HCV

Assay  Anti-HSV-Assay

Activity 

  • [Ref:Not Available]HCV:IC50: 8.2 μg mL−1

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity  No cytotoxicity information found in the reference(s) presented

Binding Target  NS3-4A protease

Mechanism  interact with the viral envelope and the phospholipids of the



Structure Information


PDB ID  None

Predicted Structure Download  No predicted structure available

Linear/Cyclic  Cyclic

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  Not includedd yet

Absent amino acids  Not included ye

Common amino acids  Not inlcuded yet

Mass  Not inlcuded yet

Pl  Not inlcuded yet

Basic residues  Not inlcuded yet

Acidic residues  Not inlcuded yet

Hydrophobic residues  2

Net charge  Not inlcuded yet

Boman Index  0.8

Hydrophobicity  Not inlcuded yet

Aliphatic Index  Not inlcuded yet

Half Life 

  •     Mammalian:Not inlcuded yet
  •     Yeast:Not inlcuded yet
  •     E.coli:Not inlcuded yet

Extinction Coefficient cystines  Not inlcuded yet

Absorbance 280nm  Not inlcuded yet

Polar residues  2



Literature Information


Literature 1

Title   Anti-HCV protease of diketopiperazines produced by the Red Sea sponge-associated fungus Aspergillus versicolor

Pubmed ID   Not Available

Reference   Applied Biochemistry and Microbiology, 53(1), 101-106.

Author   Ahmed, Eman; Rateb, Mostafa; El-Kassem, L.T. Abou ; Hawas, Usama

DOI   10.1134/S0003683817010021